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\u0648\u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0639\u0644\u0649 \u0639\u0642\u0627\u0642\u064a\u0631 \u0627\u0644\u0633\u062a\u0627\u062a\u064a\u0646\u060c \u0627\u0633\u062a\u062e\u062f\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u062c\u0632\u064a\u0626\u0627\u062a \u062a\u064f\u0639\u0631\u0641 \u0628\u0627\u0633\u0645 “\u0627\u0644\u062f\u0628\u0627\u0628\u064a\u0633 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0628\u064a\u0648\u0631\u064a\u0646” (PPRH)\u060c \u0648\u0647\u064a \u062c\u0632\u064a\u0626\u0627\u062a DNA \u0645\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u064b\u0627 \u0644\u0644\u062a\u062f\u062e\u0644 \u0641\u064a \u0646\u0634\u0627\u0637 \u062c\u064a\u0646\u0627\u062a \u0645\u062d\u062f\u062f\u0629\u060c \u0648\u0627\u0633\u062a\u064f\u062e\u062f\u0645\u062a \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u062e\u0641\u0636 \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 PCSK9.<\/p>\n
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\u0648\u062a\u062d\u0627\u0648\u0644 \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0625\u064a\u0642\u0627\u0641 \u0647\u0630\u0647 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0645\u0646 \u0645\u0635\u062f\u0631\u0647\u0627 \u0627\u0644\u0623\u0642\u0631\u0628\u060c \u0639\u0628\u0631 \u062e\u0641\u0636 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0628\u0631\u0648\u062a\u064a\u0646 PCSK9 \u0646\u0641\u0633\u0647.<\/p>\n
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\u062a\u064f\u0639\u062f “\u0627\u0644\u062f\u0628\u0627\u0628\u064a\u0633 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0628\u064a\u0648\u0631\u064a\u0646” (PPRHs) \u062c\u0632\u064a\u0626\u0627\u062a DNA \u0642\u0635\u064a\u0631\u0629 \u0623\u062d\u0627\u062f\u064a\u0629 \u0627\u0644\u0633\u0644\u0633\u0644\u0629\u060c \u062a\u064f\u0639\u0631\u0641 \u0639\u0644\u0645\u064a\u064b\u0627 \u0628\u0627\u0644\u0623\u0648\u0644\u064a\u062c\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a\u060c \u0648\u0647\u064a \u0645\u0635\u0645\u0645\u0629 \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u062a\u0633\u0644\u0633\u0644\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u062c\u062f\u064b\u0627 \u0645\u0646 DNA \u0623\u0648 RNA \u0648\u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0647\u0627. \u0648\u0628\u0645\u062c\u0631\u062f \u0627\u0631\u062a\u0628\u0627\u0637\u0647\u0627 \u0628\u0647\u062f\u0641\u0647\u0627\u060c \u064a\u0645\u0643\u0646\u0647\u0627 \u0627\u0644\u062a\u062f\u062e\u0644 \u0641\u064a \u0639\u0645\u0644\u064a\u0629 “\u0627\u0644\u0646\u0633\u062e \u0627\u0644\u062c\u064a\u0646\u064a”\u060c \u0648\u0647\u064a \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u062e\u062f\u0645\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0644\u0625\u0646\u062a\u0627\u062c RNA \u0645\u0646 \u062a\u0639\u0644\u064a\u0645\u0627\u062a DNA.<\/p>\n
\u0648\u0627\u062e\u062a\u0628\u0631 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0646\u0648\u0639\u064a\u0646 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a\u060c \u0623\u064f\u0637\u0644\u0642 \u0639\u0644\u064a\u0647\u0645\u0627 HpE9 \u0648HpE12\u060c \u0648\u0643\u0644\u0627\u0647\u0645\u0627 \u0642\u0644\u0651\u0644 \u0645\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a RNA \u0648\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062e\u0627\u0635\u064a\u0646 \u0628\u0640PCSK9\u060c \u0628\u064a\u0646\u0645\u0627 \u0631\u0641\u0639 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644 LDLR \u0627\u0644\u0630\u064a \u064a\u0633\u0627\u0639\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0639\u0644\u0649 \u0627\u0644\u062a\u0642\u0627\u0637 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0636\u0627\u0631.<\/p>\n
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\u0648\u062a\u0642\u0648\u0644 \u0627\u0644\u0623\u0633\u062a\u0627\u0630\u0629 \u0641\u064a\u0631\u0648\u0646\u064a\u0643\u0627 \u0646\u0648\u064a: “\u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0623\u0646 \u0643\u0644\u064b\u0627 \u0645\u0646 HpE9 \u0648HpE12 \u0641\u0639\u0651\u0627\u0644\u0627\u0646 \u0644\u0644\u063a\u0627\u064a\u0629 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 HepG2. \u0641\u062c\u0632\u064a\u0621 HpE12 \u064a\u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a RNA \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0640 PCSK9 \u0628\u0646\u0633\u0628\u0629 74%\u060c \u0648\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u0646\u0633\u0628\u0629 87%. \u0623\u0645\u0627 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0627\u0644\u0645\u0639\u062f\u0651\u0644\u0629 \u0648\u0631\u0627\u062b\u064a\u064b\u0627\u060c \u0641\u0642\u062f \u0623\u062f\u062a \u062d\u0642\u0646\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 HpE12 \u0625\u0644\u0649 \u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a PCSK9 \u0641\u064a \u0627\u0644\u0628\u0644\u0627\u0632\u0645\u0627 \u0628\u0646\u0633\u0628\u0629 50%\u060c \u0648\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0628\u0646\u0633\u0628\u0629 47% \u0628\u062d\u0644\u0648\u0644 \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062b\u0627\u0644\u062b.”<\/p>\n
\u0648\u062a\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0625\u0644\u0649 \u0623\u0646 \u0643\u0628\u062d \u0628\u0631\u0648\u062a\u064a\u0646 PCSK9 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0647\u0630\u0647 \u0627\u0644\u062c\u0632\u064a\u0626\u0627\u062a \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0632\u064a\u062f \u0645\u0646 \u062a\u0648\u0627\u0641\u0631 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a LDL\u060c \u0648\u064a\u0633\u0627\u0639\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0639\u0644\u0649 \u0633\u062d\u0628 \u0643\u0645\u064a\u0629 \u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0645\u0646 \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u062f\u0645\u0648\u064a\u0629.<\/p>\n
\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0627\u0644\u0623\u0645\u0631 \u064a\u062a\u0637\u0644\u0628 \u0645\u0632\u064a\u062f\u064b\u0627 \u0645\u0646 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0644\u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u0622\u0645\u0646\u064b\u0627 \u0648\u0641\u0639\u0627\u0644\u064b\u0627 \u0644\u062f\u0649 \u0627\u0644\u0628\u0634\u0631\u060c \u0646\u0638\u0631\u0627\u064f \u0644\u0623\u0646\u0647 \u062c\u0631\u0649 \u0625\u062b\u0628\u0627\u062a\u0647 \u0641\u064a \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u0641\u0642\u0637.<\/p>\n
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